感染制御プロジェクト|インフルエンザ・デング熱及び肝疾患に対する予防と治療

  • 医学研ロゴ

Achievements

Achievements

2024年

  1. Shino Shimizu, Misako Nakayama, Cong Thanh Nguyen, Hirohito Ishigaki, Yoshinori Kitagawa, Fumihiko Yasui, Yoshiki Yagi, Tomoe Kusayanagi, Michinori Kohara, Yasushi Itoh, Ichiro Tojima, Hideaki Kouzaki, Takeshi Shimizu.
    SARS-CoV-2 induces inflammation and intracranial infection through the olfactory epithelium-olfactory bulb pathway in non-human primates.
    Journal of Neuroimmunology. 2024 Feb 15;387:578288. doi: 10.1016/j.jneuroim.2024.578288.
  2. Kazi Anowar Hossain, Rupaly Akhter, Md Haroon Or Rashid, Lipi Akter1, Masashi Utsunomiya, Bouchra Kitab, Mya Myat Ngwe Tun, Takayuki Hishiki, Michinori Kohara, Kouichi Morita, Kyoko Tsukiyama-Kohara.
    Suppression of dengue virus replication by the French maritime pine extract Pycnogenol.
    Virus Research. 2024 Jan 2:339:199244. doi: 10.1016/j.virusres.2023.199244.

Achievements

2023年

  1. Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    TLR agonists as vaccine adjuvants in the prevention of viral infections: an overview.
    Frontiers in Microbiology. 2023 Dec 21:14:1249718. doi: 10.3389/fmicb.2023.1249718.
  2. Mya Myat Ngwe Tun, Khine Mya Nwe, Jean Claude Balingit, Yuki Takamatsu, Shingo Inoue, Basu Dev Pandey, Takeshi Urano, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kouichi Morita.
    A novel, comprehensive A129 mouse model for investigating dengue vaccines and evaluating pathogenesis.
    Vaccines (Basel). 2023 Dec 15;11(12):1857. doi:10.3390/vaccines11121857.
  3. Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Effects of neddylation on viral infection: an overview.
    Archives of Virology. 2023 Dec 11;169(1):6. doi: 10.1007/s00705-023-05930-3.
  4. Yutaska Furutani, Yoshinori Hirano, Mariko Toguchi, Shoko Higuchi, Xian-Yang Qin, Kaori Yanaka, Yumi Sato-Shiozaki, Nobuaki Takahashi, Marina Sakai, Pornparn Kongpracha, Takehiro Suzuki, Naoshi Dohmae, Mutsuko Kukimoto-Niino, Mikako Shirouzu, Shushi Nagamori, Harukazu Suzuki, Kaoru Kobayashi, Takahiro Masaki, Hiroo Koyama, Kazuma Sekiba, Motoyuki Otsuka, Kazuhiko Koike, Michinori Kohara, Soichi Kojima, Hideaki Kakeya, Tomokazu Matsuura.
    A small molecule iCDM-34 identified by in silico screening suppresses HBV DNA through activation of aryl hydrocarbon receptor.
    Cell Death Discovery. 2023 Dec 22;9(1):467. doi: 10.1038/s41420-023-01755-w.
  5. Takahiro Sanada, Yasunori Oda, Chinatsu Ohashi, Kentaro Isotani, Yasumasa Goh, Michinori Kohara.
    Hybrid large hepatitis B surface protein composed of two viral genotypes C and D induces strongly cross-neutralizing antibodies.
    Vaccine. 2023 Oct 13;41(43):6514-6521. doi: 10.1016/j.vaccine.2023.09.026.
  6. Kana Shiraishi, Osamu Yoshida, Yusuke Imai, Sheikh Mohammad Fazle Akbar, Takahiro Sanada, Michinori Kohara, Takashi Miyazaki, Taizou Kamishita, Teruki Miyake, Masashi Hirooka, Yoshio Tokumoto, Masanori Abe, Julio Cesar Aguilar Rubido, Gerardo Guillen Nieto, Yoichi Hiasa.
    Intranasal HBsAg/HBcAg-containing vaccine induces neutralizing anti-HBs production in hepatitis B vaccine non-responders.
    Vaccines (Basel). 2023 Sep 12;11(9):1479. doi: 10.3390/vaccines11091479.
  7. Kenzaburo Yamaji, Sadahiro Iwabuchi, Yuko Tokunaga, Shinichi Hashimoto, Daisuke Yamane, Sakiko Toyama, Risa Kono, Bouchra Kitab, Kyoko Tsukishima-Kohara*, Yosuke Osawa, Yukiko Hayashi, Tsunekazu Hishima, Chise Tateno, Kiminori Kimura, Takeshi Okanoue, Michinori Kohara.
    Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder.
    Biomedicine & Pharmacotherapy. 2023 Oct:166:115379. doi: 10.1016/j.biopha.2023.115379.
  8. Sakiko Toyama, Tomoko Honda, Sadahiro Iwabuchi, Shinichi Hashimoto, Kenzaburo Yamaji, Yuko Tokunaga, Yusuke Matsumoto, Hideya Kawaji, Takashi Miyazaki, Yoshiaki Kikkawa, Michinori Kohara.
    Application of spatial transcriptomics analysis using the Visium system for the mouse nasal cavity after intranasal vaccination.
    Frontiers in Immunology. 2023 Jul 21;14:1209945. doi: 10.3389/fimmu.2023.1209945.
  9. Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Toll-like receptor response to human immunodeficiency virus type 1 or co-infection with hepatitis B or C virus: an overview.
    International Journal of Molecular Sciences. 2023 Jun 1;24(11):9624. doi: 10.3390/ijms24119624.
  10. Moe Matsumoto, Jennifer L Modliszewski, Kotomi Shinozaki, Reona Maezawa, Vincent M Perez, Yuki Ishikawa, Ryosuke Suzuki, Kevin L McKnight, Takahiro Masaki, Asuka Hirai-Yuki, Michinori Kohara, Stanley M Lemon, Sara R Selitsky, Daisuke Yamane.
    CSNK2B modulates IRF1 binding to functional DNA elements and promotes basal and agonist-induced antiviral signaling.
    Nucleic Acids Research. 2023 May 22;51(9):4451-4466. doi: 10.1093/nar/gkad298.
  11. Eriko Inuo, Mitsuhiro Miyashita, Fumihiko Yasui, Ken Matsumura, Kentaro Sakashita, Eiji Hayashi, Masahiro Ono, Shyoji Sugii, Michinori Kohara, Masahiko Saito.
    Longitudinal changes of SARS-CoV-2 immunoglobulin G and immunoglobulin M in psychiatric disorders with coronavirus infection.
    Psychiatry and Clinical Neurosciences. 2023 Feb;77(2):124-125. doi: 10.1111/pcn.13513.
  12. Sadahiro Iwabuchi, Tomohide Tsukahara, Toshitugu Okayama, Masahiro Kitabatake, Hideki Motobayashi, Shigeyuki Shichino, Tadashi Imafuku, Kenzaburo Yamaji, Kyohei Miyamoto, Shinobu Tamura, Satoshi Ueha, Toshihiro Ito, Shin-Ichi Murata, Toshikazu Kondo, Kazuho Ikeo, Yutaka Suzuki, Kouji Matsushima, Michinori Kohara, Toshihiko Torigoe, Hiroki Yamaue, Shinichi Hashimoto.
    B cell receptor repertoire analysis from autopsy samples of COVID-19 patients.
    Frontiers in Immunology. 2023 Feb 23;14:1034978. doi: 10.3389/fimmu.2023.1034978.
  13. Naoya Otsubo, Tatsuya Fukuda, Hiroko Beppu, Chisato Maki, Fumihiko Yasui, Tomohide Hanawa, Chise Sugita, Masanori Murakami, Tetsuya Yamada, Michinori Kohara, Sachiko Wakai.
    Reduced antibody response to SARS-CoV-2 in COVID-19 patients with newly diagnosed diabetes: a retrospective observational study.
    BMC Endocrine Disorders. 2023 Jan 6;23(1):5. doi: 10.1186/s12902-023-01263-z.
  14. Takahiro Sanada, Tomoko Honda, Masahiko Higa, Kenzaburo Yamaji, Fumihiko Yasui, Michinori Kohara.
    Antibody response to third and fourth BNT162b2 mRNA booster vaccinations in healthcare workers in Tokyo, Japan.
    Journal of Infection and Chemotherapy. 2023 Mar;29(3):339-346. doi: 10.1016/j.jiac.2022.12.012.
  15. Mohammad Enamul Hoque Kayesh, Ibrahim Khalil, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Increasing dengue burden and severe dengue risk in Bangladesh: an overview.
    Tropical Medicine and infectious disease. 2023 Jan 3;8(1):32. doi: 10.3390/tropicalmed8010032.
  16. Osamu Yoshida, Sheikh Mohammad Fazle Akbar, Yusuke Imai. Takahiro Sanada, Kyoko Tsukiyama‐Kohara, Takashi Miyazaki, Taizou Kamishita, Teruki Miyake, Yoshio Tokumoto, Hayato Hikita, Masataka Tsuge, Masahito Shimizu, Mamun Al Mahtab, Julio Cesar Aguilar, Gerardo Guillen, Michinori Kohara, Yoichi Hiasa.
    Intranasal therapeutic vaccine containing HBsAg and HBcAg for patients with chronic hepatitis B; 18 months follow-up results of phase IIa clinical study Hepatology Research. 2023 Mar;53(3):196-207. doi: 10.1111/hepr.13851. 1.
  17. Takashi Toya, Yuya Atsuta, Takahiro Sanada, Tomoko Honda, Daichi Sadato, Noritaka Sekiya, Hiroko Kogure, Sonomi Takakuwa, Daishi Onai, Naoki Shingai, Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi, Kazuteru Ohashi, Yuka Harada, Michinori Kohara, Noriko Doki.
    Attenuated humoral response against SARS-CoV-2 mRNA vaccination in allogeneic stem cell transplantation recipients.
    Cancer Science. 2023 Feb;114(2):586-595. doi: 10.1111/cas.15603. 7.
  18. Wahiba Ezzemani, Anass Kettani, Subrahmanyam Sappati, Kavya Kondaka, Hicham El Ossmani, Kyoko Tsukiyama-Kohara, Haya Altawalah, Rachid Saile, Michinori Kohara, Soumaya Benjelloun, Sayeh Ezzikouri.
    Reverse vaccinology-based prediction of a multiepitope SARS-CoV-2 vaccine and its tailoring to new coronavirus variants.
    Journal of Biomolecular Structure and Dynamics. 2023 Jul;41(11):4917-4938. doi: 10.1080/07391102.2022.2075468.