感染制御プロジェクト｜インフルエンザ・デング熱及び肝疾患に対する予防と治療
  • 医学研ロゴ

Achievements

Achievements

2022年

  1. Takashi Toya, Daichi Sadato, Takahiro Sanada, Tomoko Honda, Yuya Atsuta, Noritaka Sekiya, Hiroaki Shimizu, Yuho Najima, Takeshi Kobayashi, Yuka Harada, Michinori Kohara, Noriko Doki.
    A third dose of COVID-19 mRNA vaccine induces limited humoral response in stem cell transplant recipients who got two vaccine doses before transplant.
    eJHaem. 2022 Dec 22;4(1):309-311. doi: 10.1002/jha2.637.
  2. Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Epidemiology and risk factors for acute viral hepatitis in Bangladesh: an overview.
    Microorganisms. 2022 Nov 15;10(11):2266. doi: 10.3390/microorganisms10112266.
  3. Hirohito Ishigaki, Fumihiko Yasui, Misako Nakayama, Akinori Endo, Naoki Yamamoto, Kenzaburo Yamaji, Cong Thanh Nguyen, Yoshinori Kitagawa, Takahiro Sanada, Tomoko Honda, Tsubasa Munakata, Masahiko Higa, Sakiko Toyama, Risa Kono, Asako Takagi, Yusuke Matsumoto, Aya Koseki, Kaori Hayash, Masanori Shiohara, Koji Ishii, Yasushi Saeki, Yasushi Itoh, Michinori Kohara.
    An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants.
    Frontiers Microbiology. 2022 Nov 18;13:967019. doi: 10.3389/fmicb.2022.967019.
  4. Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Takahiro Sanada, Bouchra Kitab, Md Haroon Or Rashid, Lipi Akter, Sayeh Ezzikouri, Shuko Murakami, Shintaro Ogawa, Yasuhito Tanaka, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Characterization of innate immune response to hepatitis B virus genotype F acute infection in tree shrew (Tupaia belangeri) model.
    Frontiers in Virology. 2022 Aug 18;2:926831. doi: 10.3389/fviro.2022.926831.
  5. Masamichi Kimura, Koji Nishikawa, Yosuke Osawa, Jun Imamura, Kenzaburo Yamaji, Kenichi Harada, Hiroshi Yatsuhashi, Kazumoto Murata, Kouichi Miura, Atsushi Tanaka, Tatsuya Kanto, Michinori Kohara, Terumi Kamisawa, Kiminori Kimura.
    Inhibition of CBP/β-catenin signaling ameliorated fibrosis in cholestatic liver disease.
    Hepatology Communications. 2022 Oct;6(10):2732-2747. doi: 10.1002/hep4.2043.
  6. Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    In vivo delivery tools for clustered regularly interspaced short palindromic repeat/associated protein 9-mediated inhibition of hepatitis B virus infection: an update.
    Frontiers in Microbiology. 2022 Jul 1;13:953218. doi: 10.3389/fmicb.2022.953218.
  7. Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Toll-like receptor response to hepatitis C virus infection: a recent overview.
    International Journal of Molecular Sciences. 2022 May 13;23(10):5475. doi: 10.3390/ijms23105475.
  8. Fumihiko Yasui, Yusuke Matsumoto, Naoki Yamamoto, Takahiro Sanada, Tomoko Honda, Tsubasa Munakata, Yasushi Itoh, Michinori Kohara.
    Infection with the SARS‑CoV‑2 B.1.351 variant is lethal in aged BALB/c mice.
    Scientific Reports. 2022 Mar 9;12(1):4150. doi: 10.1038/s41598-022-08104-4.
  9. Hiroko Beppu, Toshie Ogawa, Masahiro Ishikane, Tomoko Kawanishi, Tatsuya Fukuda, Lubuna Sato, Akihiro Matsunaga, Kenji Maeda, Daisuke Katagiri, Yukihito Ishizaka, Hiroaki Mitsuya, Norio Ohmagari, Fumihiko Yasui, Michinori Kohara, Kan Kikuchi, Sachiko Wakai.
    A case of COVID‐19 reinfection in a hemodialysis patient: the role of antibody in SARS‐CoV‐2 infection.
    CEN Case Reports. 2022 Nov;11(4):422-427. doi: 10.1007/s13730-022-00697-z.
  10. Makoto Kurano, Yuki Nakano, Rin Yokoyama, Yoshifumi Morita, Takuya Shimura, Chungen Qian, Fuzhen Xia, Fan He, Hiroko Ohmiya, Yoshiro Kishi, Jun Okada, Naoyuki Yoshikawa, Yutaka Nagura, Hitoshi Okazaki, Daisuke Jubishi, Kyoji Moriya, Yasuyuki Seto, Fumihiko Yasui, Michinori Kohara, Takeshi Kawamura, Tatsuhiko Kodama, Yutaka Yatomi.
    Response kinetics of different classes of antibodies to SARS-CoV2 infection in the Japanese population: the IgA and IgG titers increased earlier than the IgM titers.
    International Immunopharmacology. 2022 Feb;103:108491. doi: 10.1016/j.intimp.2021.108491. 4.
  11. Takahiro Sanada, Tomoko Honda, Fumihiko Yasui, Kenzaburo Yamaji, Tsubasa Munakata, Naoki Yamamoto, Makoto Kurano, Yusuke Matsumoto, Risa Kohno, Sakiko Toyama, Yoshiro Kishi, Takuro Horibe, Yudai Kaneko, Mayumi Kakegawa, Kazushige Fukui, Takeshi Kawamura, Wang Daming, Chungen Qian, Fuzhen Xia, Fan He, Syudo Yamasaki, Atsushi Nishida, Takayuki Harada, Masahiko Higa, Yuko Tokunaga, Asako Takagi, Masanari Itokawa, Tatsuhiko Kodama, Michinori Kohara.
    Serologic survey of IgG against SARS-CoV-2 among hospital visitors without a history of SARS-CoV-2 infection in Tokyo, 2020–2021.
    Journal of Epidemiology. 2022 Feb 5;32(2):105-111. doi: 10.2188/jea.JE20210324. 6.
  12. Karima Abounouh, Mohammad Enamul Hoque Kayesh, Haya Altawalah, Bouchra Kitab, Shuko Murakami, Shintaro Ogawa, Yasuhito Tanaka, Hind Dehbi, Pascal Pineau, Michinori Kohara, Soumaya Benjelloun, Kyoko Tsukiyama-Kohara, Sayeh Ezzikouri.
    Blocking neddylation elicits antiviral Effect against Hepatitis B Virus Replication
  13. Molecular Biology Reports. 2022 Jan;49(1):403-412. doi: 10.1007/s11033-021-06886-w. 1.
  14. Hiroko Beppu, Tatsuya Fukuda, Tomoko Kawanishi, Fumihiko Yasui, Minami Toda, Hitomi Kimura,·Yuki Nakamura, Yuka Nakamura, Kaori Kojima, Hina Ogawa, Ayumi Ishiwatari, Yuiko Kamei, Toshie Ogawa, Yasutomo Abe, Mariko Endo, Tomohide Hanawa, Rie Mizobuchi, Chise Sugita, Koh Okamoto, Shuji Hatakeyama, Tetsusya Yamada, Michinori Kohara, Sachiko Wakai.
    Hemodialysis patients with coronavirus disease 2019: reduced antibody response.
    Clinical and Experimental Nephrology. 2022 Feb;26(2):170-177. doi: 10.1007/s10157-021-02130-8. 1.
  15. Daisuke Yamane, Yuri Hayashi, Moe Matsumoto, Hiroki Nakanishi, Haruka Imagawa, Michinori Kohara, Stanley M Lemon, Ikuyo Ichi.
    FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication.
    Cell Chemical Biology. 2022 May 19;29(5):799-810.e4. doi: 10.1016/j.chembiol.2021.07.022.

Achievements

2021年

  1. Kyoko Tsukiyama-Kohara, Michinori Kohara.
    Basic study for vaccine development targeting virus infections.
    Viruses. 2021 Dec 30;14(1):57. doi: 10.3390/v14010057.
  2. Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    An overview of recent insights into the response of TLR to SARS-CoV-2 infection and the potential of TLR agonists as SARS-CoV-2 vaccine adjuvants.
    Viruses. 2021 Nov 18;13(11):2302. doi: 10.3390/v13112302.
  3. Keishi Kisoh, Go Sugahara, Yuko Ogawa, Suzue Furukawa, Yuji Ishida, Takeshi Okanoue, Michinori Kohara, Chise Tateno. Estimating drug efficacy with a diet-induced NASH model in chimeric mice with humanized livers.
    Biomedicines. 2021 Nov 9;9(11):1647. doi: 10.3390/biomedicines9111647.
  4. Asako Takagi, Yutaka Amako, Daisuke Yamane, Bouchra Kitab, Yuko Tokunaga, Ahmed El-Gohary, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Longer Poly(U) stretches in the 3'UTR are essential for replication of the hepatitis C virus genotype 4a clone in in vitro and in vivo.
    Frontiers in Microbiology. 2021 Nov 25;12:764816. doi: 10.3389/fmicb.2021.764816.
  5. Mohammad Enamul Hoque Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Toll-like receptor response to hepatitis B virus infection and potential of TLR agonists as immunomodulators for treating chronic hepatitis B: an overview.
    International Journal of Molecular Sciences. 2021 Sep 28;22(19):10462. doi: 10.3390/ijms221910462.
  6. Mohammad EH Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    A recent insight into innate immune response to dengue virus infection and vaccination.
    Frontiers in Microbiology. 2021 Sep 16;12:744233. doi: 10.3389/fmicb.2021.744233.
  7. Mohammad Enamul Hoque Kayesh, Takahiro Sanada, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Tree shrew as an emerging small animal model for human viral infection: a recent overview. Viruses. 2021 Aug 18;13(8):1641. doi: 10.3390/v13081641.
  8. Tomoko Honda, Sumiko Gomi, Daisuke Yamane, Fumihiko Yasui, Takuya Yamamoto, Tsubasa Munakata, Yasushi Itoh, Kazumasa Ogasawara, Takahiro Sanada, Kenzaburo Yamaji, Yasuhiro Yasutomi, Kyoko Tsukiyama-Kohara, Michinori Kohara.
    Development and characterization of a highly sensitive NanoLuciferase-based immunoprecipitation system for the detection of anti-influenza virus HA antibodies.
    mSphere. 2021 May12;6(3):e01342-20. doi: 10.1128/mSphere.01342-20.
  9. Liang Cheng , Guangming Li , Caroline Marnata Pellegry, Fumihiko Yasui , Feng Li , Sandra M Zurawski , Gerard Zurawski, Yves Levy , Jenny P-Y Ting , Lishan Su.
    TLR9- and CD40-targeting vaccination promotes human B cell maturation and IgG induction via pDC-dependent mechanisms in humanized mice.
    Frontiers in Immunology. 2021 May 18; 12:672143. doi: 10.3389/fimmu.2021.672143.
  10. Makoto Saito, Yasushi Itoh, Fumihiko Yasui, Tsubasa Munakata, Daisuke Yamane, Makoto Ozawa, Risa Ito, Takayuki Katoh, Hirohito Ishigaki, Misako Nakayama, Shintaro Shichinohe, Kenzaburo Yamaji, Naoki Yamamoto, Ai Ikejiri, Tomoko Honda, Takahiro Sanada, Yoshihiro Sakoda, Hiroshi Kida, Le Thi Quynh Mai, Yoshihiro Kawaoka, Kazumasa Ogasawara, Kyoko Tsukiyama-Kohara, Hiroaki Suga, Michinori Kohara.
    Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models.
    Nature Communications. 2021 May 11;12(1):2654. doi: 10.1038/s41467-021-22964-w.
  11. Bouchra Kitab, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Host-targeting antivirals for treatment of hepatitis C.
    Advances in Hepatology. 2021, 47. doi: 10.5772/intechopen.95373.
  12. Yuichi Suzuki, Haruno Onuma, Risa Sato, Yusuke Sato, Akari Hashiba, Masatoshi Maeki, Manabu Tokeshi, Mohammad E Kayesh, Michinori Kohara, Kyoko Tsukiyama-Kohara, Hideyoshi Harashima.
    Lipid nanoparticles loaded with ribonucleoprotein-oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition.
    Journal of Controlled Release. 2021 Feb 10;330:61-71. doi: 10.1016/j.jconrel.2020.12.013.