感染制御プロジェクト｜インフルエンザ・デング熱及び肝疾患に対する予防と治療
  • 医学研ロゴ

Achievements

Achievements

2020年

  1. Sayeh Ezzikouri, Jalal Nourlil, Kyoko Tsukiyama-Kohara, Michinori Kohara, Marc P Windisch, Soumaya Benjelloun.
    Nanobodies: an unexplored opportunity to combat COVID-19.
    Journal of Biomolecular Structure & Dynamics. 2020 Nov 10;1-3. doi: 10.1080/07391102.2020.1845801.
  2. Mohammad Enamul Hoque Kayesh, Yutaka Amako, Md Abul Hashem, Shuko Murakami, Shintaro Ogawa, Naoki Yamamoto, Tatsuro Hifumi, Noriaki Miyoshi, Masaya Sugiyama, Yasuhito Tanaka, Masashi Mizokami, Michinori Kohara, Kyoko Tsukiyama-Kohara. Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA.
    Virus Research. 2020 Oct 10;290:198191. doi: 10.1016/j.virusres.2020.198191.
  3. Naoki Kajiwara, Namiko Nomura, Masako Ukaji, Naoki Yamamoto, Michinori Kohara, Fumihiko Yasui, Yoshihiro Sakoda, Hiroshi Kida, Futoshi Shibasaki.
    Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus.
    Scientific Reports. 2020 Oct 22;10(1):18008. doi: 10.1038/s41598-020-74604-w.
  4. Mohcine Elmessaoudi-Idrissi, Kyoko Tsukiyama-Kohara, Jalal Nourlil, Anass Kettani, Marc P Windisch, Michinori Kohara, Yashpal Singh Malik, Kuldeep Dhama, Soumaya Benjelloun, Sayeh Ezzikouri.
    Structure-guided discovery approach identifies potential lead compounds targeting Mpro of SARS-CoV-2.
    VirusDisease. 2020 Nov 11;1-5. doi: 10.1007/s13337-020-00627-6.
  5. Kazuki Iio, Kazuhiro Uda, Hiroshi Hataya, Fumihiko Yasui, Tomoko Honda, Takahiro Sanada, Kenzaburo Yamaji, Michinori Kohara, Masanari Itokawa, Masaru Miura.
    Kawasaki disease or Kawasaki-like disease: influence of SARS-CoV-2 infections in Japan.
    Acta Paediatrica. 2020 Aug 16;10.1111/apa.15535. doi: 10.1111/apa.15535.
  6. Sayeh Ezzikouri, Mohammad Enamul Hoque Kayesh, Soumaya Benjelloun, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Targeting host innate and adaptive immunity to achieve the functional cure of chronic hepatitis.
    Vaccines. 2020 May 11;8(2):216. doi: 10.3390/vaccines8020216.
  7. Sayeh Ezzikouri, Jalal Nourlil, Soumaya Benjelloun , Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Coronavirus disease 2019—historical context, spread, virology, pathogenesis, and clinical manifestations.
    Human Vaccines & Immunotherapeutics. 2020 Aug 5;1-9. doi: 10.1080/21645515.2020.1787068.
  8. Hai-Ying Chi, Yuuki Tanaka, Tatsuro Hifumi, Ko-ichiro Shoji, Mohammad Enamu Hoque Kayesh, Md Abul Hashem, Bouchra Kitab, Takahiro Sanada, Tomoko Fujiyuki, Misako Yoneda, Hitoshi Hatai, Akira Yabuki, Noriaki Miyoshi, Chieko Kai, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Pathological and genetic aspects of spontaneous mammary gland tumor in Tupaia belangeri (Tree shrew).
    PLoS One. 2020 May 18;15(5):e0233232. doi: 10.1371/journal.pone.0233232.
  9. Yasuhiro Sakai, Andri Rezano, Seiji Okada, Takahiro Ohtsuki, Yoshiaki Kawashima, Tetsuya Tsukamoto, Motoshi Suzuki, Michinori Kohara, Motohiro Takeya, Nobuo Sakaguchi, Kazuhiko Kuwahara.
    A novel cytologic model of B-cell/macrophage biphenotypic Hodgkin lymphoma in Ganp gene-transgenic mice.
    Cancers. 2020 Jan 14;12(1). pii: E204. doi: 10.3390/cancers12010204.

Achievements

2019年

  1. Hee Sun Kim, Youngsu You, Jae Gon Mun, Changdev G. Gadhe, Hee Jo Moon, Jae Sung Lee, Ae Nim Pae, Michinori Kohara, Gyochang Keumd, Byeong Moon Kim, Sung Key Jang.
    Structure-activity relationships of fluorene compounds inhibiting HCV variants.
    Antiviral Research. 2019 Dec 17:104678. doi: 10.1016/j.antiviral.2019.104678.
  2. Takahiro Sanada, Naoki Yamamoto, Mohammad Enamul Hoque Kayesh, Kyoko Tsukiyama-Kohara, Hideki Hasegawa, Takashi Miyazaki, Jun-ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Yasumasa Goh, Osamu Yoshida, Yoichi Hiasa, Michinori Kohara.
    Intranasal vaccination with HBs and HBc protein combined with carboxyl vinyl polymer induces strong neutralizing antibody, anti-HBs IgA, and IFNG response.
    Biochemical and Biophysical Research Communications. 2019 Nov 26;520(1):86-92. doi: 10.1016/j.bbrc.2019.09.072.
  3. Takahiro Sanada, Kyoko Tsukiyama-Kohara, Tadasu Shin-I, Naoki Yamamoto, Mohammad Enamul Hoque Kayesh, Daisuke Yamane, Jun-ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Kazuho Ikeo, Takashi Gojobori, Masashi Mizokami, Michinori Kohara.
    Construction of complete Tupaia belangeri transcriptome database by whole-genome and comprehensive RNA sequencing.
    Scientific Reports. 2019 Aug 26;9(1):12372. doi: 10.1038/s41598-019-48867-x.
  4. Daisuke Yamane, Hui Feng, Efraín E Rivera-Serrano, Sara R Selitsky, Asuka Hirai-Yuki, Anshuman Das, Kevin L McKnight, Ichiro Misumi, Lucinda Hensley, William Lovell, Olga González-López, Ryosuke Suzuki, Mami Matsuda, Hiroki Nakanishi, Takayo Ohto-Nakanishi, Takayuki Hishiki, Eliane Wauthier, Tsunekazu Oikawa, Kouichi Morita, Lola M Reid, Praveen Sethupathy, Michinori Kohara, Jason K Whitmire, Stanley M Lemon.
    Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.
    Nature Microbiology. 2019 Jul;4(7):1096-1104. doi: 10.1038/s41564-019-0425-6.
  5. Bouchra Kitab, Masaaki Satoh, Yusuke Ohmori, Tsubasa Munakata, Masayuki Sudoh, Michinori Kohara, Kyoko Tsukiyama-Kohara.
    Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation.
    Journal of Biological Chemistry. 2019 Apr 12;294(15):5759-5773. doi: 10.1074/jbc.RA118.004397.
  6. Takahiro Sanada, Fumihiko Yasui, Tomoko Honda, Mohammad Enamul Hoque Kayesh, Jun-ichiro Takano, Yumiko Shiogama, Yasuhiro Yasutomi, Kyoko Tsukiyama-Kohara, Michinori Kohara. Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri).
    Virology. 2019 Mar;529:101-110. doi: 10.1016/j.virol.2019.01.015.