− この都医学研セミナーは終了しました。-
演者 | Professor Jeremy Nathans, Molecular Biology and Genetics, Neuroscience, Ophthalmology, Howard Hughes Medical Institute, Johns Hopkins Medical School, USA |
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会場 | オンライン(Zoom) |
日時 | 2021年4月22日(木曜日)10:00~ |
世話人 | 正井久雄 所長 |
参加自由 | 詳細は下記問合せ先まで |
お問い合わせ |
研究推進課 普及広報係 電話 03-5316-3109 |
Vascular development in the central nervous system (CNS) - the brain, spinal cord, and retina - is controlled by beta-catenin signaling (also called canonical Wnt signaling). Ligands produced by glia and neurons act on receptors and co-receptors on the surface of vascular endothelial cells to induce changes in gene expression that promote CNS angiogenesis. Genetic defects in receptors, ligands, co-receptors, and other auxiliary proteins result in hypovascularization and tissue hypoxia in both humans and mice. Remarkably, the same signaling system is used later in life to control development of the Blood-Brain Barrier, a CNS-specific program of gene expression that keeps toxic compounds out of the CNS and mediates active transport of essential compounds, such as glucose and amino acids, across the capillary wall. This role for beta-catenin signaling has implications for a wide variety of CNS diseases.
※ 講演は英語で行われます。
Jeremy Nathans教授は、スタンフォード大学の大学院生の時に、人間の色覚を担 うOpsin遺伝子群を世界で初めて単離、解析し、色覚のメカニズムを解明したこ とで著名です。