University Medical Center Mainz, Professor
During early development, distinct neuronal cell types and neuronal circuits are transiently expressed in the cerebral cortex. Cajal-Retzius neurons (CRNs) in the marginal zone (later cortical layer 1) and subplate neurons (SPNs) in lower cortical layer play important roles in forming the cortical architecture (layers and columns) and in guiding synaptic connectivity. Both cell types largely disappear during early development; in rodents mostly during the first postnatal week.
This talk will give an overview (1) on the unique functions of CRNs and SPNs in newborn rodent cortex, (2) how early neuronal network activity controls the maturation of the cortex, and (3) how synchronized activity patterns control the programmed cell death (apoptosis) of transient neurons.