- この都医学研セミナーは終了しました。-

Casein Kinase 1 and its history in circadian rhythms

演者	David Virshup Professor, Duke-NUS Medical School, Singapore
会場	ハイブリッド（講堂＋Zoom）
日時	2024年8月7日（水曜日）16:00～
世話人	吉種光体内時計プロジェクトリーダー
参加自由	詳細は下記問合せ先まで
お問い合わせ	研究推進課普及広報係電話 03-5316-3109

Circadian clocks regulate us, but how do we regulate the clock? Genetics, biochemistry and structural biology all point to a central role for the oddly named kinase, Casein Kinase 1 (CK1). First discovered in 1978, the CK1 family plays a part in diverse processes and diseases. Here, I will describe how CK1 was found to be a core circadian component, its multiple functions in the clock and the journey to understand how the CK1 phosphoswitch controls time.

参考文献:: 1. reviewed in Narasimamurthy and Virshup, Mol Cell, 81: 1133 (2021); 2. Masuda et al., PNAS, 117: 10888 (2020); 3. Narasimamurthy et al., PNAS, 115: 5986 (2018); 4. Zhou et al, Mol Cell, 66: 77 (2015)