| 演者 | Huilin Li Department of Structural Biology Van Andel Institute, USA |
|---|---|
| 会場 | 対面式（2階講堂） |
| 日時 | 2024年11月25日（月曜日）15:00～ |
| 世話人 | 正井 久雄 所長 |
| 参加自由 | 詳細は下記問合せ先まで |
| お問い合わせ |
研究推進課 普及広報係 電話 03-5316-3109 |
The DNA polymerase epsilon (Polε) synthesizes the bulk of leading strand DNA. However, Polε is also responsible for the C-to-G mutations, the most prevalent mutations in cancers and genetic diseases. Polε has undergone a gene duplication event during evolution, leading to an N-terminal catalytic Pol domain and a C-terminal non-catalytic Pol domain. In my talk, I will discuss how such unusual architecture leads to a highly unique molecular mechanism of the enzyme in the leading strand replisome.
