- この都医学研セミナーは終了しました。-
演者 | 池本 聡 Neurocircuitry of Motivation Section, National Institute on Drug Abuse, Section Chief |
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会場 | ハイブリッド(講堂+Zoom) |
日時 | 2023年7月25日(火曜日)16:00~ |
世話人 | 井手 聡一郎 依存性物質プロジェクト 副参事研究員 |
参加自由 | 詳細は下記問合せ先まで |
お問い合わせ |
研究推進課 普及広報係 電話 03-5316-3109 |
The supramammillary region (SuM) is a posterior hypothalamic structure, known to regulate hippocampal theta oscillations and arousal. However, the SuM plays a role in positive reinforcement, as we found that neuroactive chemicals such as nicotine activate SuM neurons for reinforcement, and that the excitation of SuM glutamatergic neurons reinforces behavior and activates mesolimbic dopamine neurons in mice. SuM neurons are active during exploration and approach behavior and inactive during sucrose consumption. Consistently, inhibition of SuM neurons disrupts approach responses, but not sucrose consumption. We propose that the SuM regulates arousal that reinforces and energizes behavioral interaction with the environment.