− この都医学研セミナーは終了しました。 −
|演者||Lucas S. Trindade（首都大学東京大学院・理工学研究科・細胞遺伝学教室 博士研究員）|
|世話人||原 孝彦 参事研究員（幹細胞プロジェクトリーダー）|
Among species, reproductive strategies are related to food availability. K-selected species (e.g. top predators - wolves) constantly struggle to find/catch food. Thus, K-selected species typically exhibit long lifespan and low fecundity. On contrary, r-selected species (e.g. preys - rabbits) have food in abundance. Thus, to optimize the available resources, r-selected species exhibit high fecundity (exponential growth) and are short-lived. Interestingly, within species we can also observe the same r- and K- reproductive strategies. Famine triggers a synchronized cascade of distinct pathways that decrease fecundity and maximize lifespan. This is equivalent to a K-program generating a K-phenotype. Inversely, ad libitum diet triggers a synchronized cascade of distinct pathways that maximize fecundity and minimize lifespan. This is equivalent to an r-program generating an r-phenotype. Therefore, universally, species have r/K-selected programs/phenotypes to better adapt to specific food conditions (named r/K system). We propose that long-term adaptation in a specific food condition is sufficient to explain all aspects of evolution in a single theory. This perspective has significant impact in several scientific fields. We describe the reasons and the genetic basis for the evolution of lifespan, fecundity, novelty, complexity and prey-predator relations. Furthermore, we highlight how this new perspective can benefit medical research.