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2019年度 医学研セミナー

Parallel dopaminergic pathways and memory circuits for memory-based action selection

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演者 Yoshinori Aso
Janelia Research Campus(Group Leader)
会場 東京都医学総合研究所 2BC会議室
日時 2019年6月19日(水) 16:00〜
世話人 副所長 齊藤 実
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電話 03-5316-3109

講演要旨

Animals discriminate stimuli and learn their predictive value based on temporal correlation with reinforcements (reward or punishment). Synaptic modulation by dopamine is essential for such associative learning and adaptive behaviors in all animal phyla. Induction of synaptic plasticity by dopaminergic neurons (DANs), in turn, affects how DANs respond to reinforcement and learned stimuli. In that way, learning adjusts how and what animals learn thereafter. Thus understanding molecular mechanisms that regulate how DANs modulate synaptic connection and intricate circuit mechanism that adaptively regulate activity of DANs, and their interplays are essential for comprehensive understanding of dopaminergic system.

Our lab is using the Drosophila mushroom body (MB), a key center for associative learning in insect brains, as a model system, where distinct subsets of 20 types of DANs write and update memories independently in each memory unit of the MB with cell-type-specific rules. I will discuss our recent findings about 1) nitric oxide function as cotransmitters of small subset of dopaminergic neurons to facilitate quick update of memory, 2) description of nanoscale synaptic structures in the MB by expansion and lattice light sheet microscopy, 3) neuronal circuit that integrate memories from MB compartments and guide memory based action selection and future learning.

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