| 演者 | John Rubenstein UCSF School of Medicine, San Francisico, CA, USA Professor |
|---|---|
| 会場 | ハイブリッド（講堂＋Zoom） |
| 日時 | 2026年2月12日（木曜日）11:00～12:00 |
| 世話人 | 丸山 千秋 脳神経回路形成プロジェクト |
| 参加自由 | 詳細は下記問合せ先まで |
| お問い合わせ |
研究推進課 普及広報係 電話 03-5316-3109 |
The embryonic basal ganglia (ganglionic eminences) generate GABAergic projection neurons for nuclei such as the striatum and globus pallidus, as well as local circuit neurons that migrate to, and integrate within the cortex and hippocampus. We have been working on the early development of the medial ganglionic eminence (MGE) and have uncovered an unexpected feature of its morphogenesis. It has a rostrodorsal growth zone that generates new ventricular zone cells that are displaced caudoventrally. Over time the transcriptional profile of these progenitors changes. We have identified a family of transcription factors that are induced as the ventricular zone matures – these proteins control the types of interneurons that are generated by the MGE.
