平成26年度 医学研セミナー

International collaborative research focusing on the oxidative stress hypothesis for novel drug development in psychiatric diseases

− この都医学研セミナーは終了しました。 −

  • 橋本 均(大阪大学大学院薬学研究科神経薬理学分野 教授)
  • James Waschek(Department of Psychiatry and Biobehavioral Sciences, UCLA Professor)
  • 松崎 伸介(大阪大学大学院 連合小児発達学研究科 分子生物遺伝学研究領域 准教授)
会場 東京都医学総合研究所 講堂
日時 平成27年1月23日(金)
  • 橋本 均:15:00~15:45
  • James Wasche:15:45~16:30
  • 松崎 伸介:16:30~17:00
世話人 糸川 昌成 参事研究員(精神行動医学研究分野)
参加自由 詳細は下記問合せ先まで
お問い合わせ 研究推進課 普及広報係


Debilitating psychiatric disorders such as schizophrenia and depression are mostly intractable and result in enormous social burden. However, the disease mechanisms are still largely unknown. Moreover, the development of novel therapeutic agents has been unsuccessful for past 20 years, indicating an urgent need to elucidate the pathogenic mechanisms and to design drugs based on novel concepts. The three speakers in this seminar have been investigating the neuronal function of PACAP (pituitary adenylate cyclase-activating polypeptide) and its signaling mechanisms as potential risk factors and drug targets for affective and cognitive dysfunction as well as schizophrenia and depression. Reports from other groups have shown that copy number variations of a PACAP receptor gene are observed in approximately 0.35% of schizophrenic patients (Vacic et al, Nature 2011), and that alterations in PACAP signaling are a risk factor for PTSD (Ressler et al, Nature 2011). In this seminar, the speakers will present their research on the role of PACAP signaling in psychiatric disorders as well as pathological conditions including oxidative stress and inflammation. Dr Hashimoto will talk about “Basic research for molecular mechanisms and drug development in psychiatric diseases”, Dr Waschek “VIP/PACAP signaling in psychiatric diseases and neuroinflammatory stress”, and Dr Matsuzaki “SUMOylation in the neural system and diseases”, respectively. It is expected that the seminar will deepen our understanding of pathogenesis of psychiatric disorders.