平成27年度 医学研セミナー

Alzheimer’s Disease Therapeutics: Challenges and Opportunities

− この都医学研セミナーは終了しました。 −

演者 Ph.D Khalid Iqbal(New York State Institute for Basic Research in Developmental Disabilities)
会場 東京都医学総合研究所 講堂
日時 平成27年4月3日(金)16:00
世話人 楯林 義孝 副参事研究員(うつ病プロジェクト)
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お問い合わせ 研究推進課 普及広報係


Cerebral aging is a major public health problem in modern society. Currently, 25 to 35 million people are estimated to be suffering from Alzheimer disease (AD) and this number is expected to triple by 2050 unless some effective treatment that can prevent or cure this major cause of dementia in middle to old age individuals is developed. To date, other than symptomatic drugs which help provide some symptomatic rescue for a relatively short term, no disease-modifying drugs for AD are available. A major challenge in developing effective AD therapeutics is the multifactorial nature of the disease and involvement of several different mechanisms. Three major approaches that are currently under development are (1) inhibition of neurodegeneration with small molecules against different targets, (2) clearance of pathological polypeptides, i.e., A? and abnormally hyperphosphorylated tau, by immunotherapy, and (3) shifting of the balance from neurodegeneration to regeneration of the brain.