− この都医学研セミナーは終了しました。 −
|演者||Prof. Brian Dean（The Florey Institute of Neuroscience and Mental Health）|
|世話人||池田 和隆 参事研究員（依存性薬物プロジェクト）|
A considerable body of data supports a role for the central cholinergic system in the aetiology of schizophrenia. There have been breakthroughs in gaining structural data on muscarinic receptors, understanding their role in CNS function and in synthesising drugs that can specifically target each of the 5 muscarinic receptors. This means it is opportune to consider the role of specific muscarinic receptors in the pathophysiology and treatment of schizophrenia. This presentation will mainly focus on data suggesting changes in levels of muscarinic M1 and M4 receptors implicate these receptors in the pathophysiology of schizophrenia. Data will also be presented that will show the mechanisms involved in reducing levels of muscarinic M1 receptor in the cortex of people with schizophrenia. Developments in understanding the roles of muscarinic M1 and M4 receptors in CNS function and how these predict mechanisms by which these receptors could induce the symptoms prevalent in schizophrenia will be discussed. Finally, there will be comments on the potential advantages and problems in targeting muscarinic M1 and M4 receptors to treat the symptoms of schizophrenia.